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Copper

J Arnaud1

  • 1Laboratoire de Biochimie C, CHRUG, Grenoble, France.

International Journal for Vitamin and Nutrition Research. Internationale Zeitschrift Fur Vitamin- Und Ernahrungsforschung. Journal International De Vitaminologie Et De Nutrition
|January 1, 1993
PubMed
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This review examines methods for assessing human copper status, highlighting their pros and cons. Current indicators are insufficient, and better biomarkers for copper status are needed.

Area of Science:

  • Biochemistry
  • Human Nutrition
  • Trace Element Metabolism

Background:

  • Copper is an essential trace element vital for numerous physiological processes.
  • Accurate assessment of copper status is crucial for diagnosing and managing related health conditions.
  • Existing methods for evaluating copper status have limitations.

Purpose of the Study:

  • To review and critically analyze static and functional indices for human copper status assessment.
  • To compare the variations, advantages, and disadvantages of different copper assessment methods.
  • To identify the need for improved biomarkers of copper status.

Main Methods:

  • Literature review of studies on human copper status assessment.
  • Analysis of static indices (e.g., serum copper, ceruloplasmin).

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  • Evaluation of functional indices (e.g., enzyme activities dependent on copper).

    • Main Results:

    • Various static and functional indices exist for assessing copper status.
    • Each index presents unique advantages and disadvantages regarding reliability and practicality.
    • No single index currently provides a comprehensive and accurate measure of copper status.

    Conclusions:

    • Current methods for assessing human copper status are inadequate.
    • Further research is required to develop superior biomarkers for copper status.
    • Improved diagnostic tools are essential for effective clinical management of copper-related disorders.