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Related Experiment Videos

Developmental changes in normal fetal bovine whole bladder physiology

D E Coplen1, E J Macarak, R M Levin

  • 1Division of Urology, Children's Hospital of Philadelphia, University of Pennsylvania 19104.

The Journal of Urology
|May 1, 1994
PubMed
Summary

Fetal bovine bladder compliance increases with development. Both smooth muscle and connective tissue in the detrusor layer are crucial for bladder function and capacity changes during fetal development.

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Area of Science:

  • Developmental Biology
  • Urology
  • Biomedical Engineering

Background:

  • Bladder compliance and capacity are critical for urinary storage and voiding.
  • Developmental changes in fetal bladder wall composition influence its mechanical properties.

Purpose of the Study:

  • To investigate the developmental changes in fetal bovine bladder compliance and capacity.
  • To determine the distinct contributions of the detrusor and mucosal layers to bladder compliance.
  • To elucidate the roles of smooth muscle and connective tissue in fetal bladder development.

Main Methods:

  • In vitro analysis of normal and experimentally altered whole fetal bovine bladders.
  • Cystometry to evaluate whole bladder compliance and capacity.
  • Assessment of bladder layers' contributions through tension elimination and surgical removal.

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Main Results:

  • Fetal bovine bladder compliance significantly increases with gestational age.
  • Eliminating active smooth muscle tension markedly improved compliance and capacity, especially in younger fetuses.
  • Surgical removal of the detrusor layer (smooth muscle and connective tissue) substantially enhanced compliance and capacity across all fetal ages.

Conclusions:

  • Both smooth muscle and connective tissue within the detrusor layer are vital components influencing fetal bladder function.
  • Developmental alterations in these bladder wall constituents are responsible for the observed physiological changes in compliance and capacity.