Related Experiment Videos
Disseminated B virus infection in a cynomolgus monkey
M A Simon1, M D Daniel, D Lee-Parritz
1Division of Comparative Pathology, Harvard Medical School, New England Regional Primate Research Center, Southborough, MA 01772-9102.
Laboratory Animal Science
|December 1, 1993
Summary
Severe peritonitis led to the euthanasia of a cynomolgus monkey. Herpes B virus infection was confirmed post-mortem, highlighting the need for universal precautions when handling macaque samples.
Area of Science:
- Veterinary Pathology
- Primate Virology
- Infectious Diseases
Background:
- Cynomolgus macaques (Macaca fascicularis) are common models in biomedical research.
- Herpes B virus (BV) is a naturally occurring herpesvirus in macaques, posing a zoonotic risk.
- Dystocia is a challenging obstetric complication in non-human primates.
Observation:
- A cynomolgus monkey presented with severe peritonitis and was euthanatized.
- Histopathology revealed disseminated lesions consistent with herpesvirus infection across multiple organs.
- Herpes B-like antigens were detected via immunohistochemistry in affected tissues.
Findings:
- Systemic Herpes B virus infection was confirmed post-mortem through viral isolation from serum.
- The infection was widespread, affecting the lungs, liver, spleen, bone marrow, uterus, adrenal gland, and serosal surfaces.
- The diagnosis of systemic B virus infection was not made prior to the animal's death.
Implications:
- These findings emphasize the critical importance of universal precautions when handling biological materials from macaques.
- Early detection and management of Herpes B virus in research settings are crucial for animal welfare and human safety.
- This case highlights potential diagnostic challenges in recognizing subclinical or rapidly progressing systemic viral infections in non-human primates.