Disseminated B virus infection in a cynomolgus monkey

A cynomolgus monkey (Macaca fascicularis) was euthanatized 1 week following dystocia because of severe peritonitis. Histologic examination revealed lesions characteristic of herpesvirus infection in lungs, liver, spleen, bone marrow, uterus, and adrenal gland, and on the serosal surface of intestines, pancreas, and reproductive tract. Immunohistochemical studies on liver and lungs revealed Herpes B-like antigens in the lesions. B virus was isolated from serum. As systemic B-virus infection was not diagnosed before death of the monkey, these findings underscore the need for universal precautions when handling blood, fluids, or tissues from macaques.