Islands and striosomes in the neostriatum of the rhesus monkey: non-equivalent compartments

Cytoarchitectonically defined cell-dense islands and regions of low acetylcholinesterase reactivity referred to as striosomes have been regarded as equivalent markers of the non-matrix compartment in the neostriatum. We examined islands and striosomes in adjacent sections to determine the degree of correspondence between the two neostriatal compartmental markers. Islands are aggregated centrally within the caudate, whereas striosomes are located throughout the entire nucleus, including the dorsolateral and ventromedial sectors. Moreover, even within the central sector, striosomes are more prevalent than islands. The present quantitative analysis suggests that islands may be further characterized as acetylcholinesterase-poor since the vast majority of islands co-localize with striosomes. However, due to the fact that striosomes are more numerous and more widely distributed throughout the neostriatum, less than a third of all striosomes are coincident with islands in adjacent sections. Comparison of each of these compartmental markers with the patterned terminal field of the prefrontal cortical projection revealed a near one-to-one correspondence between islands and terminal-free zones in the prefrontal projection. The percentage of striosomes which are aligned with fenestrations in the prefrontal projection is also quite high; however, because more striosomes than islands are found within the prefrontal terminal domain, some striosomes that fit within terminal-free zones do not have corresponding islands. These results indicate that islands and striosomes are not entirely equivalent compartmental markers and further suggest that contemporary, two-compartment models may not adequately represent the heterogeneity of the neostriatum.