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Acute pancreatitis during CAPD in The Netherlands
M M Pannekeet1, R T Krediet, E W Boeschoten
1Department of Medicine, University of Amsterdam, Utrecht, The Netherlands.
Summary
Acute pancreatitis is a serious complication for patients undergoing continuous ambulatory peritoneal dialysis (CAPD). Hypercalcemia was a common risk factor, and mortality was high, though a clear dialysate suggested a better prognosis.
Area of Science:
- Nephrology
- Gastroenterology
- Internal Medicine
Background:
- Acute pancreatitis is a rare but severe complication in patients undergoing continuous ambulatory peritoneal dialysis (CAPD).
- Understanding risk factors and outcomes is crucial for managing CAPD patients.
Purpose of the Study:
- To determine the incidence, risk factors, clinical presentation, and outcomes of acute pancreatitis in CAPD patients.
- To identify factors influencing prognosis in this patient group.
Main Methods:
- Retrospective study of CAPD patients diagnosed with acute pancreatitis in the Netherlands between 1979 and May 1992.
- Analysis of patient records, including risk factors, clinical symptoms, laboratory values (plasma and dialysate amylase), and outcomes.
Main Results:
- The incidence of acute pancreatitis was 0.46 per 100 treatment-years.
- Hypercalcemia was the most frequent risk factor identified.
- Mortality was high at 58%; a clear dialysate was associated with a better prognosis.
Conclusions:
- Acute pancreatitis is a significant concern for CAPD patients, often associated with risk factors like hypercalcemia.
- While treatment modality (CAPD vs. hemodialysis) did not significantly impact outcomes, dialysate clarity may indicate a better prognosis.