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Febrile reaction associated with urokinase
1Division of Pharmacy Practice and Science, College of Pharmacy, University of Kentucky Medical Center, Lexington.
Pharmacotherapy
|January 1, 1994
Summary
Fever is a potential adverse event during urokinase infusion for thrombotic disorders. This case report highlights urokinase-induced fever, emphasizing the need for clinical awareness of this rare side effect.
Area of Science:
- Cardiology
- Pharmacology
- Internal Medicine
Background:
- Urokinase, a human proteolytic enzyme, is utilized for treating thrombotic disorders.
- Recurrent myocardial infarction necessitates advanced treatment strategies, including intracoronary infusions.
Observation:
- A 54-year-old male patient developed fever during intracoronary urokinase infusion into a saphenous vein graft.
- The fever subsided promptly upon cessation of the urokinase infusion.
Findings:
- Urokinase was identified as the cause of the fever after other potential etiologies were ruled out.
- While some studies suggest a link between urokinase infusion and fever, this adverse event is infrequently recognized.
Implications:
- This case report underscores the importance of recognizing urokinase-induced fever as a potential adverse reaction.
- Clinicians should consider urokinase as a possible cause of fever in patients undergoing treatment for thrombotic conditions.
- Increased awareness may improve patient management and prompt recognition of this rare side effect.