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Fulminant hepatitis in dengue infection
1Department of Pediatrics, Faculty of Medicine, University of Malaya, Kuala Lumpur.
The Southeast Asian Journal of Tropical Medicine and Public Health
|September 1, 1993
Summary
Severe dengue cases can cause liver failure and encephalopathy, marked by high liver enzymes and coagulopathy. While some patients required intensive care, most dengue survivors recovered fully.
Area of Science:
- Pediatrics
- Infectious Diseases
- Hepatology
Background:
- Dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS) are severe forms of dengue infection.
- Liver failure and encephalopathy are serious complications that can arise in severe dengue cases.
Purpose of the Study:
- To investigate the occurrence and clinical characteristics of liver failure and encephalopathy in patients with severe dengue.
- To identify key indicators and outcomes associated with these severe complications.
Main Methods:
- Retrospective review of twenty patients with grade 3 and grade 4 DHF/DSS.
- Analysis of clinical data, liver enzyme levels, coagulation profiles, and neurological status.
- Assessment of interventions and patient outcomes.
Main Results:
- Eight out of twenty severe dengue patients developed liver failure and encephalopathy.
- Deterioration in mental status correlated with elevated liver enzymes (AST, ALT) and severe coagulopathy.
- Six patients required cerebral protection measures; one patient died, and another had residual hemiparesis.
Conclusions:
- Liver failure and encephalopathy are significant complications in severe dengue.
- Prompt recognition and management, including cerebral protection, are crucial.
- Most survivors achieve complete recovery of liver and neurological functions.