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Related Experiment Videos

Lactic acidosis

A H Harken

    Surgery, Gynecology & Obstetrics
    |April 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Blood lactate is a valuable surgical tool for assessing tissue oxygenation and perfusion. While not a perfect measure of intracellular conditions, its dynamic equilibrium reflects oxygen supply and pyruvate availability, aiding diagnosis and prognosis.

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    Area of Science:

    • Biochemistry
    • Physiology
    • Medical Diagnostics

    Background:

    • Establishing blood lactate as a reliable indicator of tissue oxygenation requires careful consideration of redox potentials and intracellular dynamics.
    • Intracellular lactate concentrations may not directly correlate with blood lactate levels.
    • The thermodynamic equilibrium of the intracellular lactic acid dehydrogenase system is likely incompatible with life.

    Purpose of the Study:

    • To evaluate the clinical utility of blood lactate concentration as a parameter of tissue oxygenation.
    • To explore the relationship between the lactate-pyruvate system and oxygen supply.
    • To establish the diagnostic and prognostic value of blood lactate and the lactate-to-pyruvate ratio.

    Main Methods:

    • Empirical investigation of blood lactate and lactate-to-pyruvate ratios in clinical settings.

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  • Assessment of the dynamic equilibrium of the lactate-pyruvate system in response to physiological changes.
  • Evaluation of blood lactate within the constraints of current biochemical and physiological knowledge.

    • Main Results:

    • The intracellular lactic acid dehydrogenase system likely does not exist in thermodynamic equilibrium.
    • Clinically, the lactate-pyruvate system demonstrates a dynamic equilibrium responsive to oxygen and pyruvate.
    • A stable or increased lactate-to-pyruvate ratio has established diagnostic and prognostic significance.

    Conclusions:

    • Blood lactate concentration, despite its limitations in reflecting intracellular conditions, serves as a valuable indicator of tissue perfusion.
    • The lactate-pyruvate system's dynamic equilibrium provides a clinically useful response to oxygen availability.
    • Blood lactate is an effective surgical tool when interpreted within current scientific understanding.