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Serum digoxin levels after concomitant ticarcillin and clavulanic acid administration
M Cazzola1, M G Matera, G Santangelo
1Institute of Pharmacology and Toxicology, Medical School, Second University, Naples, Italy.
Therapeutic Drug Monitoring
|February 1, 1994
Summary
Concomitant use of ticarcillin and clavulanic acid did not significantly alter serum digoxin levels in patients with chronic bronchitis. Digoxin efficacy and safety remain predictable when co-administered with this antibiotic combination.
Area of Science:
- Pharmacology
- Clinical Pharmacy
- Internal Medicine
Background:
- Antibiotics can alter serum digoxin concentrations, potentially affecting efficacy and safety.
- Understanding drug interactions is crucial for optimizing patient care.
Purpose of the Study:
- To evaluate the effect of ticarcillin and clavulanic acid on serum digoxin levels.
- To assess potential modifications in digoxin pharmacokinetics during co-administration.
Main Methods:
- A study involving 15 hospitalized patients with chronic bronchitis exacerbation.
- Patients received both digoxin and a combination of ticarcillin and clavulanic acid.
- Serum digoxin concentrations were monitored.
Main Results:
- Serum digoxin levels were not significantly altered by the co-administration.
- A slight decrease in peak digoxin concentrations was observed.
- Average time to maximum concentration and 24-hour area under the curve remained unchanged.
Conclusions:
- Ticarcillin and clavulanic acid do not significantly impact steady-state serum digoxin levels.
- Digoxin's therapeutic range is likely maintained when used with this antibiotic combination.
- This finding supports the continued use of digoxin in patients requiring treatment with ticarcillin and clavulanic acid.