[Transport of 2,5-dimethoxy-4-methylamphetamine by macroheterocycles across erythrocyte membranes]

Transport of 2,5-dimethoxy-4-methylamphetamine across human erythrocytes by the 18-crown-6, monoaza-15-crown-5 and diaza-18-crown-6 is studied and evaluated spectrophotometrically. It is shown that crown-ethers at low concentration (1-2 mM) protect erythrocytes against their natural homolysis. 2,5-dimethoxy-4-methylamphetamine provides 2-5% hemolysis of erythrocytes. In the presence of macrocycles (5 mM) hemolysis of erythrocytes increases from 6.5 to 30%. A hemolytic effect of 2,5-dimethoxy-4-methylamphetamine depends on the structure of the crown ethers and, apparently, confirms significant role of complexes of the crown-ethers with amine in these processes.