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[Diagnostic performance of eosinophil protein quantification. Review]
A Escudero Pastor1, J Hernández García
1Hospital Rafael Méndez, Lorca, Murcia.
Allergologia Et Immunopathologia
|November 1, 1993
Summary
Eosinophil granular proteins, like eosinophil cationic protein, are key in atopic diseases and asthma. Their measurement aids in diagnosing and monitoring these conditions, and even predicts pregnancy outcomes.
Area of Science:
- Immunology
- Cell Biology
- Biochemistry
Context:
- Eosinophils play a significant role in various disorders, including atopic diseases, parasitic infections, neoplasms, and immune deficiencies.
- Activated eosinophils release cytotoxic granular proteins such as principal basic protein (PBP), eosinophil cationic protein (ECP), eosinophil-derived neurotoxin (EDN), and eosinophil peroxidase (EPO).
Purpose:
- To highlight the importance of understanding eosinophil granular proteins' biological functions and tissue concentrations.
- To discuss the utility of sensitive radioimmunoassays for measuring these proteins in various body fluids.
- To explore the diagnostic and prognostic value of quantifying these proteins in clinical settings.
Summary:
- Eosinophil granular proteins exhibit cytotoxic effects on target cells and organisms.
- Quantification of proteins like ECP and PBP in biological fluids (serum, sputum, lavage fluid) is feasible using radioimmunoassays.
- Elevated levels of PBP in late pregnancy may predict term gestation.
Impact:
- Knowledge of eosinophil protein concentrations aids in understanding the pathophysiology of diverse disorders.
- Quantitation of granular proteins can serve as a biomarker for monitoring disease activity, such as in bronchial asthma.
- These measurements may help predict delayed asthmatic reactions and inform pregnancy management.