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Related Experiment Videos

Cardiovascular changes during continuous hyperthermic peritoneal perfusion

N Shime1, M Lee, T Hatanaka

  • 1Department of Anesthesiology, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kyoto, Japan.

Anesthesia and Analgesia
|May 1, 1994
PubMed
Summary

Continuous hyperthermic peritoneal perfusion (CHPP) for intraperitoneal cancer causes significant cardiovascular and oxygen transport changes. These hemodynamic shifts are primarily linked to systemic hyperthermia and other factors during the procedure.

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Area of Science:

  • Oncology
  • Cardiovascular Physiology
  • Medical Technology

Background:

  • Continuous hyperthermic peritoneal perfusion (CHPP) is a therapeutic technique for intraperitoneal cancer.
  • Understanding the physiological impact of CHPP is crucial for patient management.

Purpose of the Study:

  • To evaluate changes in blood temperature, hemodynamics, and oxygen transport during CHPP.
  • To identify the contributing factors to these physiological alterations.

Main Methods:

  • Hemodynamic and oxygen transport parameters were monitored in 11 patients undergoing CHPP.
  • Blood temperature was measured using a pulmonary artery catheter thermistor.

Main Results:

  • Systemic hyperthermia reached 39.2°C, with increased heart rate and cardiac index.

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  • Mean arterial pressure and systemic vascular resistance index decreased.
  • Oxygen consumption significantly increased, with a smaller rise in oxygen delivery and slight increase in oxygen extraction.

    • Conclusions:

    • CHPP induces substantial cardiovascular and oxygen transport modifications.
    • Systemic hyperthermia is the primary driver of these changes, alongside splanchnic heating, abdominal distention, and pharmacological agents.