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[Syringoma and trisomy 21]

L Thomas1, N Chamchikh, D Audefray

  • 1Service de Dermatologie, Hôpital de l'Antiquaille, Lyon.

Annales De Dermatologie Et De Venereologie
|January 1, 1993
PubMed
Summary

Syringoma, a skin condition, is significantly more common in individuals with Down syndrome (trisomy 21). This report details two cases, highlighting the non-fortuitous association between syringoma and trisomy 21.

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Area of Science:

  • Dermatology
  • Clinical Genetics

Background:

  • Syringomas are benign adnexal tumors originating from the eccrine sweat ducts.
  • Trisomy 21, also known as Down syndrome, is a genetic disorder associated with characteristic physical features and developmental delays.

Observation:

  • Two cases of syringoma in women with trisomy 21 are presented.
  • The first patient, aged 29, had multiple eyelid syringomas.
  • The second patient, aged 44, presented with disseminated syringomas.

Findings:

  • The association between syringoma and trisomy 21 is statistically significant, occurring 31 times more frequently than in the general population.
  • While eyelid syringomas are commonly reported in trisomy 21, disseminated syringomas are rare, with only four previous cases documented.

Implications:

  • The findings suggest a potential genetic or biological link between syringoma development and trisomy 21.
  • Further research is warranted to elucidate the underlying mechanisms of this association.
  • This highlights the importance of dermatological surveillance in individuals with trisomy 21.

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