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The immediate effect of TSH on renal iodide excretion rate in rabbits
Abstract:
The renal iodide excretion rate was determined in unrestrained female rabbits by means of conventional clearance technique or continuous monitoring of the whole body disappearance of iv injected 125I-iodide using an implanted Geiger-Muller detector. The immediate effect of pharmacological doses of bovine TSH was studied by both methods and a significant decrease in iodide excretion rate was recorded following the administration of a single TSH dose of 4 IU. The effect of TSH lasted 3-6 h. Injection of 10-20 mug TRH caused a transient delay in iodide disappearance (30-50 min) while 2-20 mug triiodothyronine iv or sc had no immediate effect on the iodide disappearance.
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