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Bupropion overdose and seizure

¹Department of Emergency Medicine, Joint Military Medical Centers, Lackland Air Force Base, San Antonio, TX 78236-5300.

The American Journal of Emergency Medicine

|March 1, 1994

Summary

This case study presents the first reported pure bupropion overdose in emergency medicine literature. An 18-year-old female experienced seizures and tachycardia but fully recovered after ingesting 9g of bupropion.

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Area of Science:

Emergency Medicine
Clinical Toxicology
Pharmacology

Background:

Bupropion is a widely prescribed novel antidepressant with limited data on overdose toxicity.
Understanding bupropion overdose is crucial for emergency medical management.

Observation:

An 18-year-old healthy female intentionally ingested 9 grams of bupropion.
The patient presented with grand mal seizures and sinus tachycardia.

Findings:

The patient experienced significant central nervous system and cardiovascular effects.
Complete neurological recovery was achieved without long-term sequelae.

Implications:

This case highlights the potential for severe toxicity with bupropion overdose.
It underscores the need for prompt recognition and management of bupropion toxicity in emergency settings.

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