Osseous substance formation induced in porous calcium phosphate ceramics in soft tissues

Porous calcium phosphate ceramics prepared according to the methods of laboratories in Leiden were implanted subcutaneously in rats for 3, 6 and 12 w. No bone formation could be observed. Porous calcium phosphate ceramics prepared according to the methods of laboratories in Sichuan were implanted subcutaneously/intramuscularly in dogs for 1, 3, 5 and 7 months. In particular, ceramics containing alpha-tricalcium phosphate evoked bone formation in the pores of the ceramics. The amount of bone was similar at the different time periods.