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Does lansoprazole influence postprandial digestive function?

N Vidon1, C Dutreuil, J C Scoule

  • 1Laboratoire de pharmacie galénique, faculté de Pharmacie, Paris, France.

Alimentary Pharmacology & Therapeutics
|December 1, 1993
PubMed
Summary
This summary is machine-generated.

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Proton pump inhibitors like lansoprazole significantly reduce gastric acid and gastric emptying volume but do not alter meal gastric emptying or biliary-pancreatic secretion in healthy individuals.

Area of Science:

  • Gastroenterology
  • Pharmacology

Background:

  • Proton pump inhibitors (PPIs) are widely used to reduce gastric acid production.
  • The impact of potent PPIs on overall digestive function requires further elucidation.

Purpose of the Study:

  • To investigate the effects of lansoprazole, a potent proton pump inhibitor, on postprandial digestive functions.
  • To compare the effects of lansoprazole with a placebo in healthy volunteers.

Main Methods:

  • A double-blind, randomized crossover study was conducted with six healthy male volunteers.
  • Participants received either 30 mg/day of lansoprazole or a placebo for 7 days, followed by a 14-day washout period.

Main Results:

  • Lansoprazole significantly decreased 3-h gastric acid secretion and the volume of gastric contents emptying into the duodenum compared to placebo (P < 0.05).

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  • However, lansoprazole did not alter meal gastric emptying half-times, duodenal lipase and chymotrypsin outputs, or bile acid outputs.
  • No changes were observed in the kinetic profiles of biliary-pancreatic secretion.

    • Conclusions:

    • Chronic administration of a proton pump inhibitor at a usual therapeutic dose effectively inhibits gastric secretion.
    • This inhibition does not affect meal gastric emptying or postprandial biliary-pancreatic secretion in healthy individuals.