Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Lean body mass estimation by creatinine kinetics

P R Keshaviah1, K D Nolph, H L Moore

  • 1Baxter Clinical Engineering Laboratory, Minneapolis, MN 55404.

Journal of the American Society of Nephrology : JASN
|January 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Klinefelter syndrome in a Holstein-Friesian bull: a case report.

Irish veterinary journal·2026
Same author

Design and evaluation of a custom circulating tumour DNA assay to detect endometrial cancer recurrence.

NPJ precision oncology·2026
Same author

Placement, management and complications associated with peripheral intravenous catheter use in UK small animal practice.

The Journal of small animal practice·2024
Same author

Correction to: Primary care usage at the end of life: a retrospective cohort study of cancer patients using linked primary and hospital care data.

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer·2024
Same author

Management of isolated anomalous systemic arterial supply to normal lung (ISSNL) during pregnancy.

QJM : monthly journal of the Association of Physicians·2024
Same author

Primary care usage at the end of life: a retrospective cohort study of cancer patients using linked primary and hospital care data.

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer·2024
Same journal

Variants to Functions to Therapeutic Strategies Toward Genomically Informed Care for Autosomal Dominant Polycystic Kidney Disease.

Journal of the American Society of Nephrology : JASN·2026
Same journal

Personalizing Cardio-Kidney-Metabolic Therapy: Closer But Not There Yet.

Journal of the American Society of Nephrology : JASN·2026
Same journal

Autosomal Dominant Tubulointerstitial Kidney Disease: My Kingdom for a Biomarker.

Journal of the American Society of Nephrology : JASN·2026
Same journal

Beyond the Margin: Improving Noninferiority Trials of Kidney Transplant Immunosuppression.

Journal of the American Society of Nephrology : JASN·2026
Same journal

Parathyroid Hormone Receptor 1 Facilitates Cyst Growth in Genetic Models of Autosomal Dominant Polycystic Kidney Disease.

Journal of the American Society of Nephrology : JASN·2026
Same journal

Alanyl-tRNA Synthetase 1 and Cyst Growth in Autosomal Dominant Polycystic Kidney Disease.

Journal of the American Society of Nephrology : JASN·2026
See all related articles

A new method uses creatinine kinetics to estimate lean body mass (LBM), proving useful for assessing nutritional status in dialysis patients. This technique offers a simple, convenient approach for routine monitoring.

Area of Science:

  • Biochemistry
  • Clinical Nutrition
  • Nephrology

Background:

  • Lean body mass (LBM) is a key indicator of nutritional status.
  • Accurate LBM estimation is crucial for managing patients with chronic kidney disease undergoing dialysis.
  • Existing methods for LBM assessment have limitations in accuracy and convenience.

Purpose of the Study:

  • To develop and validate a novel technique for estimating LBM based on creatinine kinetics.
  • To compare the creatinine kinetics method with established techniques for LBM assessment.
  • To assess the utility of creatinine kinetics for nutritional assessment in hemodialysis (HD) and peritoneal dialysis (PD) patients.

Main Methods:

  • Developed a technique estimating LBM from creatinine kinetics, assuming proportionality between creatinine production and LBM in a steady state.

Related Experiment Videos

  • Applied the technique to normal subjects, stable HD patients, and stable PD patients.
  • Compared LBM estimates from creatinine kinetics with bioimpedance, total body water, near infrared, and anthropometric methods in various patient groups.

    • Main Results:

    • Creatinine kinetics-based LBM correlated significantly with LBM derived from total body water and bioimpedance in HD patients.
    • In PD patients and normal subjects, LBM by creatinine kinetics showed significant correlations with other methods but yielded lower values.
    • A substantial proportion of HD (47%) and PD (66%) patients exhibited lower LBM by creatinine kinetics than expected for their demographics.

    Conclusions:

    • Estimation of LBM by creatinine kinetics is a simple and convenient technique.
    • This method is proposed for routine nutritional assessment in dialysis patients.
    • The findings suggest potential underestimation of LBM in a significant number of dialysis patients using this kinetic method.