Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bone marrow transplantation for aplastic anemia

R Storb1

  • 1Fred Hutchinson Cancer Research Center, Seattle, WA 98104-2092.

Cell Transplantation
|September 1, 1993
PubMed
Summary

Improved survival in aplastic anemia patients undergoing marrow transplants is linked to reduced graft rejection and acute graft-versus-host disease (GvHD). Research focuses on optimizing conditioning and transfusion strategies to enhance outcomes and prevent long-term GvHD complications.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Allogeneic marrow transplantation during untreated first relapse of acute myeloid leukemia.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology·1992
Same author

Pharmacologic, toxicologic, and marrow transplantation studies in dogs given succinyl acetone.

Transplantation·1992
Same author

Treatment of acute graft-versus-host disease with a nonmitogenic anti-CD3 monoclonal antibody.

Transplantation·1992
Same author

Succinyl acetone plus methotrexate as graft-versus-host disease prophylaxis in DLA-haploidentical canine littermate marrow grafts.

Transplantation·1992
Same author

Specific growth inhibition of primitive hematopoietic progenitor cells mediated through monoclonal antibody binding to major histocompatibility class II molecules.

Blood·1992
Same author

Acute graft-versus-host disease: analysis of risk factors after allogeneic marrow transplantation and prophylaxis with cyclosporine and methotrexate.

Blood·1992

Area of Science:

  • Hematology
  • Immunology
  • Transplantation Medicine

Background:

  • Aplastic anemia treatment survival has improved with human leukocyte antigen (HLA)-identical marrow transplants.
  • Key factors include reduced graft rejection and acute graft-versus-host disease (GvHD).

Purpose of the Study:

  • To review advancements in marrow transplantation for aplastic anemia.
  • To discuss strategies reducing graft rejection and GvHD.
  • To highlight long-term sequelae and future research directions.

Main Methods:

  • Analysis of pre-transplant transfusion strategies, including white blood cell removal and in vitro irradiation.
  • Evaluation of immunosuppressive conditioning regimens, comparing radiation-based protocols with cyclophosphamide/antithymocyte globulin.
  • Assessment of methotrexate/cyclosporine for acute GvHD prophylaxis.

Main Results:

  • Judicious transfusions and improved conditioning regimens decrease graft rejection.
  • Cyclophosphamide/antithymocyte globulin shows promise, with low rejection rates.
  • Methotrexate/cyclosporine effectively reduces acute GvHD incidence and severity.
  • Radiation-based regimens are associated with secondary malignancies and are not recommended for HLA-identical recipients.

Conclusions:

  • Optimized transfusion and immunosuppression protocols significantly improve survival in aplastic anemia patients.
  • Prevention of chronic GvHD is crucial, with ongoing studies on extended cyclosporine use.
  • Future research should focus on less toxic conditioning regimens to mitigate long-term risks like secondary cancers.

Related Experiment Videos