Psychogenic seizures in adults: a longitudinal analysis

Area of Science:

• Neurology
• Psychiatry
• Clinical Psychology

Background:

• Psychogenic seizures (PS) are a complex neurological and psychiatric condition.
• Understanding the clinical characteristics and psychosocial factors is crucial for effective management.

Purpose of the Study:

• To analyze the clinical characteristics, psychosocial background, neuropsychological findings, and outcomes of adults with psychogenic seizures.
• To identify potential predictors of prognosis in this patient population.

Main Methods:

• Retrospective analysis of 93 adult patients diagnosed with psychogenic seizures.
• Evaluation included clinical assessment, psychosocial history, and neuropsychological testing.
• Follow-up data was collected to assess seizure status and social impact.

Main Results:

• The study included 93 adults (86% female, mean age 31.7 years) with psychogenic seizures.
• Neuropsychological testing revealed prevalent hysteroid traits, maladaptive coping mechanisms, and depression.
• A history of sexual abuse was reported in 10.7% of cases.
• Significant social impact was observed, with 34 of 62 working patients unable to work post-diagnosis.
• After a mean follow-up of 60.7 months in 63 patients, 16 (25.4%) became seizure-free.
• No significant predictors of poor prognosis were identified.

Conclusions:

• Psychogenic seizures in adults are associated with significant psychosocial challenges, including underlying psychiatric conditions and substantial social disability.
• While a quarter of patients achieved seizure freedom, the prognosis remains variable without clear predictive factors.
• Further research into integrated treatment approaches addressing both neurological and psychological aspects is warranted.