Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Seizures associated with fluoxetine therapy

V P Prasher1

  • 1Department of Psychiatry, University of Birmingham, UK.

Seizure
|December 1, 1993
PubMed
Summary

Fluoxetine, an antidepressant, rarely causes seizures. This review examines five reported cases, including a new case in a person with Down syndrome.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Folate, vitamin B(12), Down syndrome and Alzheimer's disease.

International journal of geriatric psychiatry·2016
Same author

Rivastigmine transdermal patches in the treatment of dementia in Alzheimer's disease in adults with Down syndrome-pilot study.

International journal of geriatric psychiatry·2013
Same author

Plasma beta-amyloid and duration of Alzheimer's disease in adults with Down syndrome.

International journal of geriatric psychiatry·2009
Same author

Significant effect of APOE epsilon 4 genotype on the risk of dementia in Alzheimer's disease and mortality in persons with Down syndrome.

International journal of geriatric psychiatry·2008
Same author

Total serum cholesterol levels and Alzheimer's dementia in patients with Down syndrome.

International journal of geriatric psychiatry·2008
Same author

Season of birth: dementia in Alzheimer's disease in adults with Down Syndrome.

International journal of geriatric psychiatry·2007

Area of Science:

  • Neuroscience
  • Pharmacology
  • Clinical Medicine

Background:

  • Fluoxetine is a widely prescribed selective serotonin reuptake inhibitor (SSRI) antidepressant.
  • It is generally associated with a favorable side-effect profile.
  • Seizures are an uncommon but recognized potential adverse effect of fluoxetine therapy.

Observation:

  • This report details a novel case of fluoxetine-induced seizures in an individual with Down syndrome.
  • The case is reviewed alongside five previously documented instances of seizures linked to fluoxetine treatment.
  • The clinical presentation and circumstances surrounding these seizure events are analyzed.

Findings:

  • Seizures associated with fluoxetine are rare, occurring in a small fraction of patients.
  • The occurrence of seizures may be influenced by underlying patient factors, such as genetic conditions like Down syndrome.
  • A comprehensive review of existing literature and the presented case highlights the need for vigilance.

Implications:

  • Clinicians should be aware of the potential for fluoxetine-induced seizures, particularly in vulnerable populations.
  • Further research may be warranted to elucidate the mechanisms underlying seizure risk with fluoxetine.
  • This information is crucial for optimizing antidepressant therapy and patient safety in clinical practice.

Related Experiment Videos