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ICA1 encoding p69, a protein linked to the development of type 1 diabetes, maps to human chromosome 7p22
R Gaedigk1, A M Duncan, I Miyazaki
1Hospital for Sick Children Research Institute, Department of Paediatrics, Toronto, Ontario, Canada.
Cytogenetics and Cell Genetics
|January 1, 1994
Abstract:
The development of type 1 (insulin dependent) diabetes mellitus (IDDM) requires a genetically susceptible host and exposure, early in life, to environmental trigger molecules that induce diabetic autoimmunity to insulin producing islet cells. We previously identified islet cell protein p69 as a candidate autoimmune target in IDDM. Here we describe a human genomic p69 fragment which allowed us to map the gene (ICA1) to chromosome 7p22.