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[Churg-Strauss syndrome]

A Bodenseh1, C Klepzig, D Schön

  • 1Innere Abteilung, Rotes-Kreuz-Krankenhaus, Frankfurt/Main.

Deutsche Medizinische Wochenschrift (1946)
|April 22, 1994
PubMed
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Churg-Strauss syndrome, a rare condition, was diagnosed in a woman with asthma and allergies presenting with respiratory symptoms and high eosinophil counts. Prompt prednisone treatment led to rapid symptom resolution and long-term remission.

Area of Science:

  • Internal Medicine
  • Pulmonology
  • Rheumatology

Background:

  • Churg-Strauss syndrome (CSS) is a rare multisystemic vasculitis characterized by asthma, eosinophilia, and granulomatous inflammation.
  • CSS often presents with diverse symptoms, including respiratory issues, constitutional symptoms, and potential organ damage.

Observation:

  • A 41-year-old woman presented with a 6-week history of dyspnea, myalgia, fever, and malaise.
  • She had a history of allergic rhinitis, bronchial asthma, and maxillary sinusitis.
  • Physical examination revealed marked pleuropulmonary shadows on chest radiograph, elevated erythrocyte sedimentation rate, and significant peripheral eosinophilia (74%).

Findings:

  • Diagnostic workup excluded other conditions like pulmonary aspergillosis, Wegener granulomatosis, and hypereosinophilic leukemia.

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  • Transbronchial lung biopsy confirmed interstitial and intra-alveolar infiltration by eosinophils, establishing the diagnosis of Churg-Strauss syndrome.
  • Serological tests for antineutrophil cytoplasmic antibodies (pANCA and cANCA) were negative.

    • Implications:

    • Early diagnosis and treatment with corticosteroids, such as prednisone, are crucial for managing Churg-Strauss syndrome.
    • This case highlights the importance of considering CSS in patients with asthma and eosinophilia presenting with pulmonary infiltrates.
    • Effective treatment resulted in rapid symptom improvement and sustained remission, underscoring the efficacy of prednisone therapy.