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Related Experiment Videos

Nail-patella syndrome and pre-eclampsia

M Casellas1, R R Tey, A Segura

  • 1Obstetrics and Gynaecology Department, Maternity and Infants' Hospital, Barcelona, Spain.

European Journal of Obstetrics, Gynecology, and Reproductive Biology
|December 30, 1993
PubMed
Summary

This case study details the first reported instance of Nail-patella syndrome (NPS) during pregnancy. The pregnancy was complicated by preeclampsia and intrauterine fetal death, with NPS-related kidney issues emerging during gestation.

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Area of Science:

  • Obstetrics and Gynecology
  • Nephrology
  • Medical Genetics

Background:

  • Nail-patella syndrome (NPS) is a rare genetic disorder affecting bone, nail, and kidney development.
  • Pregnancy in women with NPS is uncommon, and its impact on maternal and fetal outcomes is not well-documented.

Observation:

  • This report describes the first case of NPS diagnosed in a pregnant patient.
  • The pregnancy was complicated by early-onset preeclampsia at 22 weeks gestation.
  • Intrauterine fetal demise occurred at 24 weeks gestation.

Findings:

  • The patient exhibited clinical signs of NPS-related nephropathy during pregnancy.
  • Postpartum, the patient developed isolated proteinuria.
  • Eighteen months postpartum, the proteinuria progressed to nephrotic syndrome.

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Implications:

  • This case highlights the potential for severe obstetric and renal complications in pregnant patients with NPS.
  • It underscores the importance of close monitoring of renal function in pregnant women with NPS.
  • Further research is needed to understand the risks and management strategies for NPS in pregnancy.