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Sequences of the oxytetracycline polyketide synthase-encoding otc genes from Streptomyces rimosus
E S Kim1, M J Bibb, M J Butler
1Department of Microbiology, University of Minnesota, St. Paul 55108.
Gene
|April 8, 1994
Abstract:
The complete nucleotide sequences of the Streptomyces rimosus oxytetracycline (oxyTc) polyketide synthase (PKS)-encoding genes (otcY) has been determined, revealing three open reading frames. The deduced amino-acid sequences correspond to the presumed heterodimeric beta-ketoacyl synthase and acyl carrier protein found in other type-II (multicomponent) PKS systems that specify construction of acetate-derived polyketide antibiotics.