Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Polymorphism of the mouse transcription factor-encoding gene E2A

S A Marlow1, P H Kay, J M Papadimitriou

  • 1Department of Pathology, University of Western Australia, Nedlands.

Gene
|April 20, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Endoplasmic reticulum mediates mitochondrial transfer within the osteocyte dendritic network.

Science advances·2019
Same author

Erratum: Author Correction: Exosomes-the enigmatic regulators of bone homeostasis.

Bone research·2019
Same author

Exosomes-the enigmatic regulators of bone homeostasis.

Bone research·2018
Same author

AIDS in Africa: distinguishing fact and fiction.

World journal of microbiology & biotechnology·2014
Same author

Cytomegalovirus primary envelopment at large nuclear membrane infoldings: what's new?

Journal of virology·2007
Same author

Bone allograft non-union is related to excessive osteoclastic bone resorption: a sheep model study.

Histology and histopathology·2006

Researchers discovered two forms of the E2A gene in mice. One form is common across most mouse strains, while a rarer variant exists in wild Mus musculus domesticus populations.

Area of Science:

  • Genetics and Genomics
  • Molecular Biology
  • Mammalian Genetics

Background:

  • The E2A gene plays a crucial role in various biological processes.
  • Understanding genetic variation within mouse populations is essential for research.
  • Previous studies have not fully characterized the diversity of the E2A gene.

Purpose of the Study:

  • To investigate the genetic diversity of the E2A gene in different mouse strains.
  • To identify and differentiate distinct forms of the E2A gene.
  • To determine the prevalence of E2A gene variants in wild mouse populations.

Main Methods:

  • Southern blotting analysis was employed to detect variations in the E2A gene.
  • A cDNA probe targeting the central coding region of E12 (a form of E2A) was synthesized.

Related Experiment Videos

  • Analysis included inbred and wild mouse strains from Mus musculus musculus and Mus musculus domesticus.

    • Main Results:

    • Two distinct forms of the E2A gene were identified through Southern blotting.
    • A common E2A form was found in all analyzed inbred and wild mouse strains.
    • A less common E2A variant was exclusively detected in the wild Mus musculus domesticus population.

    Conclusions:

    • The E2A gene exhibits genetic variation within mouse populations.
    • A specific variant of the E2A gene is present in wild Mus musculus domesticus.
    • These findings contribute to the understanding of mouse genetic diversity and evolution.