Anterior spinal artery syndrome

Area of Science:

• Neurology
• Vascular Surgery
• Interventional Radiology

Background:

• Anterior spinal artery syndrome presents with significant neurological deficits, including paraparesis, sensory loss, and sphincter dysfunction.
• The etiology of anterior spinal artery syndrome can be diverse, often presenting without clear causative factors.
• Effective treatment strategies for acute anterior spinal artery syndrome remain a critical area of clinical research.

Observation:

• Three patients presenting with acute anterior spinal artery syndrome underwent direct arterial perfusion therapy.
• The treatment involved targeted delivery of dexamethasone sodium phosphate and urokinase into the artery of Adamkiewicz.
• Therapeutic interventions were administered in three consecutive sessions, spaced one week apart, during the early disease phase.

Findings:

• All three patients demonstrated a positive clinical response to the direct perfusion therapy.
• Significant improvement in neurological symptoms, including motor function, sensory perception, and sphincter control, was observed.
• The treatment approach was well-tolerated, with no immediate adverse events reported.

Implications:

• Direct arterial perfusion of dexamethasone and urokinase represents a promising therapeutic option for anterior spinal artery syndrome.
• This interventional strategy may offer a pathway to improved recovery outcomes in patients with this condition.
• Further research is warranted to validate these findings and establish standardized treatment protocols.