Related Experiment Video

Updated: Aug 12, 2026

Experimental and Imaging Techniques for Examining Fibrin Clot Structures in Normal and Diseased States
07:09

Experimental and Imaging Techniques for Examining Fibrin Clot Structures in Normal and Diseased States

Published on: April 1, 2015

Stroke in Fabry's disease

R P Grewal

    Journal of Neurology
    |January 1, 1994
    PubMed

    Insights

    Cerebrovascular complications, such as ischemic strokes, frequently affect patients with Fabry

    Area of Science:

    • Neurology
    • Genetics
    • Vascular Medicine

    Background:

    • Fabry disease is a rare genetic disorder.
    • It affects multiple organs, including the brain.
    • Cerebrovascular complications are a known concern.

    Observation:

    • Thirty-three patients with Fabry disease were reviewed.
    • Eight patients (24%) experienced cerebrovascular events.
    • These events primarily involved ischemic strokes in small arteries.

    Findings:

    • Strokes occurred in both carotid and vertebrobasilar territories.
    • Most strokes (6/8) happened before age 40.
    • Small artery thrombosis due to Fabry disease is the likely cause.

    Implications:

    • Stroke is a significant cause of morbidity in Fabry disease.
    • Early-onset strokes are common.
    • Understanding these complications is crucial for patient management.

    More Related Videos

    Ferric Chloride-induced Thrombosis Mouse Model on Carotid Artery and Mesentery Vessel07:26

    Ferric Chloride-induced Thrombosis Mouse Model on Carotid Artery and Mesentery Vessel

    Published on: June 29, 2015

    A Fibrin-Enriched and tPA-Sensitive Photothrombotic Stroke Model09:42

    A Fibrin-Enriched and tPA-Sensitive Photothrombotic Stroke Model

    Published on: June 4, 2021

    Related Concept Videos

    Rheumatic Heart Disease I: Introduction01:23

    Rheumatic Heart Disease I: Introduction

    Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
    Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

    Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

    The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
    Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

    Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

    Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
    Ischemic Stroke l: Introduction01:15

    Ischemic Stroke l: Introduction

    Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
    Hemorrhagic Stroke l: Introduction01:17

    Hemorrhagic Stroke l: Introduction

    A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...
    Hemorrhagic Stroke ll: Pathophysiology01:29

    Hemorrhagic Stroke ll: Pathophysiology

    A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...