[Tuberculous meningoencephalitis with primary destruction of the cranial base and secondary development of multiple...

A 34-year-old Vietnamese patient presented with tuberculous meningoencephalitis complicated by hydrocephalus, diabetes insipidus, and radiological evidence of skull base erosion. Despite antituberculous treatment and corticosteroids multiple basal tuberculomas developed. Because of unusual CT and MRI findings casting some doubt on the diagnosis, brain biopsy was performed. The histological finding of an intracerebral tuberculoma supported the initial diagnosis. Some aspects of differential diagnosis and therapy are discussed, with reference to this case.