Related Experiment Video

Updated: Aug 8, 2026

From a 2DE-Gel Spot to Protein Function: Lesson Learned From HS1 in Chronic Lymphocytic Leukemia
10:18

From a 2DE-Gel Spot to Protein Function: Lesson Learned From HS1 in Chronic Lymphocytic Leukemia

Published on: October 19, 2014

[A case of progressive multifocal leucoencephalopathy during chronic lymphocytic leukaemia]

T Nowak-Michalska1, M Barcikowska, E Kida

  • 1Kliniki Neurologicznej II Wydz. Lek. AM, Warszawie.

Neurologia I Neurochirurgia Polska
|November 1, 1993
PubMed

Insights

This case study details Progressive Multifocal Leukoencephalopathy (PML) in untreated chronic lymphocytic leukemia. Diagnosis confirmed JC virus in brain tissue, highlighting a rare complication.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Oncology

Background:

  • Chronic lymphocytic leukemia (CLL) is a common hematologic malignancy.
  • Progressive Multifocal Leukoencephalopathy (PML) is a rare, opportunistic demyelinating disease.
  • PML is caused by the JC polyomavirus (JCV).

Observation:

  • A case of PML was observed in a patient with untreated CLL.
  • Histological examination revealed focal demyelination, abnormal oligodendroglia with intranuclear inclusions, and bizarre astrocytes in the white matter.
  • Electron microscopy identified JC virus particles within the nuclei of abnormal oligodendrocytes and astrocytes.

Findings:

  • Immunohistochemistry confirmed the presence of JC virus antigens in brain tissue.
  • In-situ hybridization detected JC virus genomic DNA in oligodendroglial nuclei.
  • These findings established the diagnosis of PML in the context of CLL.

Implications:

  • This case underscores the importance of considering PML in immunocompromised patients, including those with CLL.
  • Early diagnosis and understanding of JCV pathogenesis are crucial for managing neurological complications in leukemia patients.
  • Further research may elucidate the specific mechanisms linking untreated CLL to increased PML risk.

More Related Videos

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up09:01

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up

Published on: March 26, 2018

Flow Cytometric Analysis of Lymphocyte Infiltration in Central Nervous System during Experimental Autoimmune Encephalomyelitis09:01

Flow Cytometric Analysis of Lymphocyte Infiltration in Central Nervous System during Experimental Autoimmune Encephalomyelitis

Published on: November 17, 2020

Related Concept Videos

Disorders of Leukocytes01:27

Disorders of Leukocytes

Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune system...
Cryptococcal Meningitis01:27

Cryptococcal Meningitis

Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...
Encephalitis l: Introduction01:19

Encephalitis l: Introduction

Encephalitis is inflammation of the brain parenchyma, most often due to infections or autoimmune processes. It presents with neuropsychiatric features such as fever, altered mental status, behavioral changes, cognitive dysfunction, seizures, focal deficits, and sometimes autonomic instability. In some cases, the meninges are also involved, resulting in meningoencephalitis.Infectious CausesInfectious encephalitis is most commonly viral but can also result from bacterial, fungal, or parasitic...
Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...