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Evaluation of retinoids as therapeutic agents in dermatology
1Research Triangle Institute, Research Triangle Park, North Carolina 27709.
Pharmaceutical Research
|February 1, 1994
Abstract:
Evaluation of 13-cis-12-substituted analogues of retinoic acid in a series of dermatologic screens has revealed that structural modifications can lead to selectivity and specificity. An analogue, 11-cis,13-cis-12-hydroxymethylretinoic acid, delta-lactone, has been found to have good activity and to be devoid of topical and systemic toxicity.