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[Cooperative binding of tolbutamide by isolated rat Islets of Langerhans]
Comptes Rendus Hebdomadaires Des Seances De L'Academie Des Sciences. Serie D: Sciences Naturelles
|December 22, 1975
Rat islets of Langerhans isolated with collagenase bind tolbutamide, an antidiabetic sulfonylurea. Binding shows a cooperative relationship in the range of concentrations of tolbutamide (less than 10(-4) M) which are known to elicit a dose-related stimulation of insulin secretion.
Rat islets of Langerhans isolated with collagenase bind tolbutamide, an antidiabetic sulfonylurea. Binding shows a cooperative relationship in the range of concentrations of tolbutamide (less than 10(-4) M) which are known to elicit a dose-related stimulation of insulin secretion.