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Current concepts in autologous bone marrow transplantation
1Autologous Bone Marrow Transplant Unit, Duke University Medical Center, Durham, NC 27710.
Seminars in Oncology Nursing
|February 1, 1994
Summary
High-dose chemotherapy and radiation therapy, known as bone marrow transplantation (BMT), can be used to treat diseases. Autologous BMT uses the patient's own marrow or stem cells, with research ongoing into purging malignant cells and using only peripheral blood progenitor cells (PBPCs).
Area of Science:
- Oncology
- Hematology
- Transplantation Medicine
Background:
- Bone marrow transplantation (BMT) is a critical therapeutic modality for various diseases.
- It involves high-dose chemotherapy and/or radiation therapy followed by bone marrow rescue.
- Autologous BMT utilizes the patient's own harvested stem cells.
Purpose of the Study:
- To describe the principles of autologous bone marrow transplantation.
- To highlight the sources of stem cells used in autologous BMT.
- To identify current research directions in autologous BMT.
Main Methods:
- Harvesting bone marrow or peripheral blood progenitor cells (PBPCs) from the patient.
- Administering high-dose chemotherapy and/or radiation therapy.
- Infusing the collected autologous stem cells for marrow rescue.
Main Results:
- Autologous BMT enables the use of intensive treatment regimens by restoring hematopoietic function.
- Peripheral blood progenitor cells (PBPCs) offer an alternative source for stem cell transplantation.
- The efficacy of marrow purging techniques is under investigation.
Conclusions:
- Autologous BMT is a well-established treatment involving patient-derived stem cells.
- The use of PBPCs is a key area of development in autologous transplantation.
- Ongoing research focuses on improving the safety and efficacy of autologous BMT, particularly through cell purging.