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Related Experiment Videos

Functional study of the dermal microcirculation in systemic sclerosis

A J Geirsson1, G S Jónsson, L P Asgeirsdóttir

  • 1Department of Internal Medicine, Landspitalinn, Reykjavik, Iceland.

Scandinavian Journal of Rheumatology
|January 1, 1994
PubMed
Summary

Digital blood pressure significantly drops in systemic sclerosis and Raynaud

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Area of Science:

  • Vascular Medicine
  • Dermatology
  • Rheumatology

Background:

  • Systemic sclerosis (SSc) and primary Raynaud's phenomenon (PRP) are characterized by cold intolerance.
  • Digital blood pressure response to cooling is a key indicator of vascular health in these conditions.

Purpose of the Study:

  • To assess the impact of cooling on digital blood pressure in patients with SSc and PRP.
  • To evaluate the dermal microcirculatory response to local heating in SSc patients.

Main Methods:

  • Digital blood pressure was measured using strain-gauge and photoplethysmography during controlled cooling to 10°C.
  • Laser-Doppler technique quantified skin perfusion changes in response to local heating at five body sites.
  • Study groups included 18 SSc patients, 25 PRP individuals, and 30 healthy controls.

Main Results:

  • Cooling to 10°C induced a significant digital blood pressure drop (58 mmHg in SSc, 61 mmHg in PRP) compared to controls.
  • Dermal microcirculation in SSc patients showed a normal response to local heating, with perfusion increasing comparably to healthy individuals.

Conclusions:

  • Patients with SSc experience a substantial decrease in digital blood pressure upon cooling.
  • Despite cold intolerance, the dermal microvasculature in SSc patients demonstrates a normal response to local heating.

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