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Hormone-dependent spinal leiomyoma
R E Hekster1, N Lambooy, E V van Hall
1Department of Radiology, Leyenburg Hospital, Den Haag, The Netherlands.
Surgical Neurology
|April 1, 1994
Summary
A woman with a cervical spinal leiomyoma experienced symptom recurrence. Treatment with Danazol (Danatrol) until menopause resolved symptoms and prevented tumor growth, allowing medication discontinuation.
Area of Science:
- Gynecologic Oncology
- Neurosurgery
- Endocrinology
Background:
- Spinal leiomyomas are rare benign tumors, often presenting with symptoms related to spinal cord compression or instability.
- Recurrence of leiomyomas, particularly in hormonally sensitive locations, can occur after surgical resection.
Observation:
- A 43-year-old woman with a history of subtotal removal for cervical spinal leiomyoma experienced recurrent symptoms and demonstrated tumor regrowth.
- Cyclic symptoms suggested a hormonal influence on the leiomyoma's behavior.
Findings:
- The patient was treated with Danazol (Danatrol), a synthetic anti-gonadotropic hormone, to manage recurrent cervical spinal leiomyoma.
- Continuous treatment with Danazol until menopause effectively controlled symptom recurrence and tumor growth.
Implications:
- Hormonal therapy, such as Danazol, may be a viable treatment option for managing recurrent spinal leiomyomas, especially in premenopausal women.
- Menopause appears to halt the progression of residual cervical spinal leiomyoma, suggesting a role for estrogen and progesterone in tumor growth.