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Contact signalling and cell motility

D Gingell1

  • 1Department of Anatomy and Developmental Biology, University College London, UK.

Symposia of the Society for Experimental Biology
|January 1, 1993
PubMed
Summary
This summary is machine-generated.

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Cell adhesion triggers intracellular signals via transmembrane glycoprotein aggregation, influencing cell movement. This study explores the molecular mechanisms and cytoskeletal dynamics behind cell motility.

Area of Science:

  • Cell Biology
  • Biophysics
  • Molecular Biology

Background:

  • Cell adhesion is crucial for multicellular organisms.
  • Cellular signaling pathways are activated upon cell adhesion.
  • Transmembrane glycoproteins play a key role in cell adhesion.

Purpose of the Study:

  • To investigate the signaling mechanisms initiated by cell adhesion.
  • To elucidate the role of transmembrane glycoprotein aggregation in signal generation.
  • To model cell motility based on adhesion-mediated signals and cytoskeletal dynamics.

Main Methods:

  • Analysis of intracellular signaling pathways.
  • Investigation of transmembrane glycoprotein aggregation at adhesion sites.
  • Examination of cytoskeletal architecture and dynamics in lamellar extensions.

Related Experiment Videos

  • Development of motility models based on experimental data.

    • Main Results:

    • Cell adhesion, particularly with extracellular matrix or other cells, generates intracellular signals.
    • Aggregation of transmembrane glycoproteins at adhesion sites triggers these signals.
    • Molecular clustering influences cell spreading and motility through signal transduction pathways.
    • Cytoskeletal dynamics in lamellar extensions are linked to adhesion-mediated signals.

    Conclusions:

    • Adhesion-generated signals, driven by glycoprotein clustering, are fundamental to cell motility.
    • Understanding the molecular components and cytoskeletal rearrangements provides insights into cell movement.
    • Further research can refine models of lamellar motility modulation by adhesion signals.