Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Oxygen tension regulates osteoblast function

O C Tuncay1, D Ho, M K Barker

  • 1University of Mississippi Medical Center, Department of Orthodontics, Jackson.

American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics
|May 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Barriers and Facilitators to Topical Fluoride Varnish Application in Well-Child Visits.

JDR clinical and translational research·2025
Same author

Interconnected pathways link faecal microbiota plasma lipids and brain activity to childhood malnutrition related cognition.

Nature communications·2025
Same author

Integrative analysis reveals novel insights into juvenile idiopathic arthritis pathogenesis and shared molecular pathways with associated traits.

Frontiers in genetics·2024
Same author

Designing Calcium Silicate Cements with On-Demand Properties for Precision Endodontics.

Journal of dental research·2023
Same author

Juvenile idiopathic arthritis-associated genetic loci exhibit spatially constrained gene regulatory effects across multiple tissues and immune cell types.

Journal of autoimmunity·2023
Same author

Ground and In-Flight Calibration of the OSIRIS-REx Camera Suite.

Space science reviews·2020
Same journal

Smile frameworks defined by the patient's facial pattern: A cross-sectional study.

American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics·2026
Same journal

Evaluation of the correlation between dental arch width and dentofacial parameters using cone-beam computed tomography: A retrospective analysis.

American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics·2026
Same journal

Patient experiences with orthodontic retention and retainers: A scoping review.

American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics·2026
Same journal

We are there for you.

American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics·2026
Same journal

Considerations concerning credit cards.

American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics·2026
Same journal

Thieves of thought: Plagiarism in scientific writing.

American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics·2026
See all related articles

Oxygen levels significantly impact bone remodeling. Hypoxia (low oxygen) boosts osteoblast proliferation, while hyperoxia (high oxygen) enhances their activity, suggesting oxygen tension is a key factor in bone repair and tooth movement.

Area of Science:

  • Biomedical Engineering
  • Cell Biology
  • Orthodontics

Background:

  • Oxygen availability in the periodontium influences alveolar bone remodeling.
  • This process is comparable to bone growth and fracture healing mechanisms.

Purpose of the Study:

  • To investigate the impact of ambient hypoxia and hyperoxia on osteoblast function in vitro.
  • To understand the role of oxygen tension in regulating bone remodeling during tooth movement.

Main Methods:

  • Osteoblast-enriched cultures from fetal rat calvariae were used.
  • Cells were exposed to hyperoxia (90% O2) and hypoxia (10% O2).
  • Assays included media pH, pO2, pCO2, cellular proliferation, alkaline phosphatase (AP) activity, and collagen synthesis.

Related Experiment Videos

Main Results:

  • Hypoxia increased cellular proliferation but decreased AP activity, collagen synthesis, and pO2/pCO2.
  • Hyperoxia suppressed proliferation but increased AP activity, collagen synthesis, and pO2/pCO2.
  • Media pH remained unaffected by oxygen conditions.

Conclusions:

  • Oxygen tension acts as a critical environmental factor triggering bone remodeling.
  • Changes in oxygen availability can reversibly alter osteoblast metabolic activity.
  • Findings support the regulatory role of oxygen in alveolar bone remodeling during orthodontic tooth movement.