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[Hyperinsulinemic hypoglycemia: a study of four cases]

J Féliz-De Vargas Pastor1, I García Jiménez, F Sánchez Miramón

  • 1Sección de Lactantes, Hospital Infantil Miguel Servet, Zaragoza.

Anales Espanoles De Pediatria
|December 1, 1993
PubMed
Summary

Hyperinsulinemia can cause severe hypoglycemia and seizures in infants. This review proposes a diagnostic algorithm for prompt identification and effective management of this rare condition.

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Area of Science:

  • Pediatric Endocrinology
  • Neonatal Neurology
  • Metabolic Disorders

Context:

  • Hyperinsulinemia is a significant cause of persistent hypoglycemia in neonates.
  • Neurological symptoms, such as seizures, are often the initial presentation.
  • Timely diagnosis is crucial for preventing long-term neurological sequelae.

Purpose:

  • To present a review of four cases of hyperinsulinemic hypoglycemia.
  • To propose a diagnostic algorithm for hypoglycemia.
  • To discuss diagnostic tests, treatment, and patient outcomes.

Summary:

  • Four cases of hyperinsulinemic hypoglycemia presenting with early-onset seizures and subsequent hypoglycemia were diagnosed.
  • A diagnostic algorithm for managing hypoglycemia is suggested.

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  • Details on diagnostic approaches, therapeutic interventions, and patient follow-up are provided.

    • Impact:

    • This work aids in the early diagnosis and management of hyperinsulinemic hypoglycemia.
    • The proposed algorithm can guide clinicians in evaluating infants with hypoglycemia.
    • Improved understanding of treatment and outcomes can enhance patient care and prognosis.