Related Experiment Video
Updated: Aug 6, 2026

Through the Looking Glass: Time-lapse Microscopy and Longitudinal Tracking of Single Cells to Study Anti-cancer Therapeutics
Published on: May 14, 2016
Small cell lung cancer and topoisomerases
1Department of Oncology, Free University Hospital, Amsterdam, The Netherlands.
Abstract:
Topoisomerases are nuclear enzymes involved in steps of DNA metabolism which require topological modifications. Interestingly, these enzymes have been discovered to be targets of several anticancer drugs in common clinical use. Alterations of the topoisomerase enzymes have been described as associated with the development of drug resistance to topoisomerase inhibitors. The best known alterations are reduced gene expression and mutations in the genes. The present knowledge of the role of topoisomerases in lung cancer, and in small cell lung cancer in particular, is described here.
Related Concept Videos
DNA Helicases
DNA Topoisomerases
Types and Mechanism of action
Topoisomerases are divided into two main types. Type I...
Conservative Site-specific Recombination and Phase Variation
The recognition sites for Cre recombinase called LoxP...
Targeted Cancer Therapies
There are several types of targeted therapies against specific...
Treatment Resistant Cancers
Inhibitors of Bacterial DNA Synthesis

