[Prevention of endogenous infectious complications in patients after severe trauma and orthopedic surgery]

The clinical efficacy of a complex procedure for the prophylaxis of purulent septic complications in patients requiring pulmonary artificial ventilation after severe traumata and orthopedic operations, as well as in patients with the endoprosthetic appliance of the hip joint and the resection of bone tumors was studied. The procedure includes a selective decontamination of the gastrointestinal tract and oral cavity, the oral administration of lactic acid bifidum-bacterin (eubiotic) during the entire period of the pulmonary artificial ventilation and a short-term systemic administration of a 3rd generation cephalosporin. The autoflora and microflora of the pathologic foci in the patients were tested. There were observed regularities in the colonization of the mucous membranes and wounds with aerobic opportunistic organisms and the endogenic pattern of the infectious complications in the patients subjected to the pulmonary artificial ventilation. The use of the complex procedure for the prophylaxis resulted in a significant decrease in the number of the patients with purulent septic complications.