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Molecular cloning of a cDNA encoding a novel fatty acid-binding protein from rat skin
1Department of Biochemistry, Niigata University School of Medicine, Japan.
Biochemical and Biophysical Research Communications
|April 15, 1994
Abstract:
A novel skin-type fatty acid-binding protein, termed cutaneous(C)-FABP, has been purified from rat skin and a cDNA clone for this protein has been identified. The purified protein had the ability to bind long chain fatty acids like other rat FABPs. The deduced amino acid sequence of the cDNA clone comprises residues yielding a molecular mass for the polypeptide of 15.1 kDa and exhibits around 50% identity to myelin P2 protein, adipocyte FABP and heart FABP. Our results propose that C-FABP is a new member of the FABP family.