Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Apoptosis in dog thyroid cells

S Dremier1, J Golstein, R Mosselmans

  • 1Institut de Recherche Interdisciplinaire en Biologie Humaine et Nucléaire (IRIBHN), Faculté de Médecine, Free University of Brussels (U.L.B), Belgium.

Biochemical and Biophysical Research Communications
|April 15, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Development and validation of an in vitro model to study thrombin generation on the surface of catheters in platelet-poor and platelet-rich plasma.

Thrombosis research·2024
Same author

3D reconstruction of the left atrium for precise localisation and ablation of accessory pathway.

Acta cardiologica·2022
Same author

Contrast ultrasound for the quantification of deep vein thrombosis in living mice: effects of enoxaparin and P2Y12 receptor inhibition.

Journal of thrombosis and haemostasis : JTH·2013
Same author

Extracellular nucleotide derivatives protect cardiomyocytes against hypoxic stress.

Biochemical pharmacology·2011
Same author

The purinergic receptor P2Y2 receptor mediates chemotaxis of dendritic cells and eosinophils in allergic lung inflammation.

Allergy·2010
Same author

Distal colonic Na(+) absorption inhibited by luminal P2Y(2) receptors.

Pflugers Archiv : European journal of physiology·2007
Same journal

The plasma membrane H<sup>+</sup>-ATPase OSA2 negatively regulates salt tolerance in rice seedlings.

Biochemical and biophysical research communications·2026
Same journal

MiR-425-5p modulation of CREB1 affects inflammatory response and motor recovery after spinal cord injury.

Biochemical and biophysical research communications·2026
Same journal

Xanthoangelol, a chalcone from Angelica keiskei, induces apoptosis in cervical cancer cell lines via the oxidative stress-mediated activation of caspase-8 and caspase-9.

Biochemical and biophysical research communications·2026
Same journal

Suchilactone ameliorates podocyte injury in membranous nephropathy by modulating the JNK/p38 MAPK pathway in vitro.

Biochemical and biophysical research communications·2026
Same journal

Palmitic acid-induced metabolic stress alters differentiation-associated gene expression in human ameloblast-like cells.

Biochemical and biophysical research communications·2026
Same journal

A transferrin receptor-based vector enables robust Type-II membrane protein display on mammalian cells.

Biochemical and biophysical research communications·2026
See all related articles

Thyroid cells undergo programmed cell death (apoptosis) when deprived of essential growth factors. This natural cell loss mechanism may explain thyroid tissue regression in vivo.

Area of Science:

  • Cell Biology
  • Endocrinology
  • Histology

Background:

  • Apoptosis, or programmed cell death, is crucial for tissue homeostasis and regression.
  • Thyroid cell populations normally maintain balance through cell turnover.
  • Thyrotropin (TSH) influences thyroid cell population size.

Purpose of the Study:

  • To investigate the role of apoptosis in dog thyroid cell population changes.
  • To determine if apoptosis is triggered by deprivation of growth factors and thyrotropin.
  • To explore the constitutive apoptosis program in thyrocytes.

Main Methods:

  • Primary culture of dog thyroid cells.
  • Deprivation of serum, epidermal growth factor, and thyrotropin.
  • Induction of apoptosis using cycloheximide.

Related Experiment Videos

  • Assessment of internucleosomal DNA fragmentation and morphological changes.

    • Main Results:

    • Serum, EGF, and thyrotropin deprivation induced apoptosis in dog thyroid cells.
    • Characteristic apoptotic morphological changes were observed.
    • Internucleosomal DNA fragmentation confirmed apoptotic cell death.
    • Cycloheximide also triggered apoptotic cell death.

    Conclusions:

    • Dog thyroid cells possess a constitutive apoptosis program.
    • This intrinsic apoptosis mechanism likely contributes to thyroid regression in vivo when growth stimulation is insufficient.