[Infusion therapy complications in newborn and nursing infants]
Related Experiment Videos
Insights
Infusion therapy complications in infants under six months, including traumatic injuries and acute renal insufficiency (ARI), were analyzed. Hyalin thrombi formation resulted from solution damage to endothelium and blood changes, while ARI was linked to kidney overloading.
Area of Science:
- Pediatric Medicine
- Neonatology
- Pathology
Context:
- Analysis of 306 infant case histories (under 6 months) undergoing infusion therapy.
- Focus on complications arising during intravenous administration of medicinal and nutrient solutions.
- Identification of five major complication categories.
Purpose:
- To analyze complications associated with subclavical vein infusion therapy in critically ill infants.
- To investigate the mechanisms behind observed complications, including hyalin thrombi and acute renal insufficiency (ARI).
- To assess the role of infusion solutions and fluid overload in infant mortality.
Summary:
- Complications observed included traumatic injuries, air embolism, thrombosis, diffuse hyalin thrombi in lung vessels, and acute renal insufficiency (ARI).
- Hyalin thrombi formation is attributed to endothelial damage from solutions and altered blood properties (erythrocytes, plasma).
- Acute renal insufficiency (ARI) is linked to infusion overloading in immature infant kidneys.
Impact:
- Highlights potential risks of infusion therapy in neonates and young infants.
- Informs clinical practice regarding careful administration of intravenous fluids and medications.
- Underscores the vulnerability of immature renal systems to fluid overload.
Abstract:
The case histories of 306 babies dying at the age under 6 months were analysed. All the babies were given medicinal and nutrient solutions mainly via the subclavical veins for different diseases. In the process of the infusion therapy complications were observed which were distributed into 5 groups: 1--traumatic injuries, 2--air embolism, 3--thrombosis, 4--diffuse hyalin thrombi predominantly in the lung vessels, 5--acute renal insufficiency (ARI). Formation of the hyalin thrombi appeared to be due to the damaging effect of the administered solutions on the vascular endothelium and changes in the properties of erythrocytes and blood plasma. In the development of ARI some importance is ascribed to infusion overloading of the structurally and functionally immature kidneys of young infants.