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Testing the Efficacy of Pharmacological Agents in a Pericardial Target Delivery Model in the Swine
Published on: July 7, 2016
Cardiac anesthesia risk management. Multicenter outcome research
1Multicenter Study of Perioperative Ischemia Research Group, San Francisco, CA, UCSF, Veterans Affairs Medical Center 94121.
Insights
Perioperative cardiovascular morbidity poses a significant healthcare challenge, costing billions annually. Large-scale therapeutic trials are crucial for developing effective treatments to reduce heart attack and stroke risks in surgical patients.
Area of Science:
- Cardiology
- Neurosurgery
- Health Economics
Background:
- Perioperative cardiovascular morbidity is a major healthcare challenge, impacting millions of patients undergoing surgery annually.
- Current costs associated with perioperative cardiovascular morbidity are substantial, encompassing both in-hospital and post-hospitalization care.
- Despite advancements in early detection, perioperative heart and brain infarctions remain critical issues.
Purpose of the Study:
- To highlight the significant burden of perioperative cardiovascular morbidity and its associated costs.
- To emphasize the need for large-scale therapeutic trials to improve patient outcomes.
- To introduce the McSPI Research Group's focus on addressing heart attack and stroke in the perioperative setting.
Main Methods:
- Review of existing data on perioperative cardiovascular morbidity and associated healthcare costs.
- Discussion of past and present strategies for managing perioperative cardiovascular and central nervous system morbidity.
- Introduction of the McSPI Research Group as a platform for future research.
Main Results:
- Perioperative cardiovascular morbidity incurs significant financial costs, estimated in the billions of dollars annually.
- Over one million patients in the U.S. experience postsurgical cardiovascular morbidity each year.
- Existing technologies for early detection of infarction surrogates have not sufficiently resolved the problem of perioperative infarctions.
Conclusions:
- Future advancements in perioperative care necessitate large-scale therapeutic trials.
- The McSPI Research Group aims to identify effective therapies for perioperative cardiovascular and neurological events.
- The group also focuses on fostering the academic development of clinical investigators in this field.
Abstract:
Perioperative cardiovascular morbidity represents a major health-care challenge. Morbidity after coronary artery surgery annually consumes $750 million in health-care resources in-hospital and about $500 million in posthospitalization care. Of the 25 million patients who undergo noncardiac surgery annually in the United States, more than 1 million suffer postsurgical cardiovascular morbidity. The annual in-hospital cost of this morbidity is $10 billion, with posthospitalization care costing $12 billion more. Early efforts to reduce perioperative cardiovascular and central nervous system morbidity focused largely on the development and use of technologies designed to achieve earlier detection of end-point surrogates. However, despite advances in the early detection of infarction surrogates, perioperative heart and brain infarctions remain urgent problems. Future advances in perioperative care will require large-scale therapeutic trials of agents intended to alter outcome. The McSPI Research Group is a unique international, multicenter research organization focused on the problems of heart attack and stroke, with the goals of identifying not only effective therapies, but also developing the academic careers of clinical investigators.
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