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Monocyte tissue factor in treated Hodgkin's disease
W D Haire1, S J Pirruccello, S D Carson
1Department of Internal Medicine, University of Nebraska Medical Center.
Leukemia & Lymphoma
|January 1, 1994
Summary
Thrombosis is a complication of Hodgkin's disease. Elevated tissue factor on monocytes, a clotting factor, was found in some patients, potentially contributing to thrombosis risk.
Area of Science:
- Hematology
- Oncology
Background:
- Thrombosis is a known complication in Hodgkin's disease.
- The underlying mechanisms for thrombosis in Hodgkin's disease remain unclear.
Purpose of the Study:
- To investigate the functional expression of tissue factor on peripheral blood monocytes in patients with relapsed Hodgkin's disease.
- To explore the relationship between tissue factor levels and thrombotic events in this patient population.
Main Methods:
- Assessed functional tissue factor expression on peripheral blood monocytes.
- Analyzed 14 consecutive patients with relapsed Hodgkin's disease.
- Correlated tissue factor activity with patient characteristics and thrombotic complications.
Main Results:
- Marked elevations in monocyte tissue factor activity were observed in over half of the patients.
- Tissue factor activity showed a wide range (75-fold variation).
- Higher tissue factor levels were associated with male patients who had not undergone splenectomy; three patients with the highest levels experienced thrombotic complications.
Conclusions:
- Monocyte tissue factor may contribute to thrombosis in some Hodgkin's disease patients.
- Elevated tissue factor is characteristic of a subpopulation, suggesting other factors are involved.
- Patient, therapy, and disease-specific variables likely influence thrombosis development in Hodgkin's disease.