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Updated: Aug 15, 2026

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Associated Chromosome Trap for Identifying Long-range DNA Interactions
Published on: April 23, 2011
Carrier detection in X-linked immunodeficiencies. I: A PCR-based X chromosome inactivation assay at the MAOA locus
R W Hendriks1, Z Y Chen, H Hinds
1Department of Biochemistry, University of Oxford, UK.
Abstract:
We developed an X chromosome inactivation PCR assay, based on differential methylation of the 5' CpG island of the monoamine oxidase A gene (MAOA), close to a highly polymorphic region just downstream of the first exon. The assay provides a method to determine the carrier status of females from pedigrees with X-linked immunodeficiency diseases (XLID).

