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Related Experiment Videos

Perireceptor events in taste

H Schmale1, C Ahlers, M Bläker

  • 1Institut für Zellbiochemie und klinische Neurobiologie, Universität Hamburg, Germany.

Ciba Foundation Symposium
|January 1, 1993
PubMed
Summary
This summary is machine-generated.

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Salivary proteins from von Ebner's glands (VEGs) may interact with tastants. These lipocalin proteins, found in human, rat, and pig saliva, might transport hydrophobic molecules or protect taste epithelia.

Area of Science:

  • Biochemistry
  • Sensory Science
  • Molecular Biology

Background:

  • The perireceptor milieu, including saliva, influences chemical ligand-receptor interactions at taste receptor sites.
  • Lingual von Ebner's glands (VEGs) secrete proteins into the saliva, particularly in taste bud-rich papillae.
  • Understanding salivary components is crucial for elucidating taste perception mechanisms.

Purpose of the Study:

  • To characterize a prominent 18 kDa secretory protein from von Ebner's glands (VEGs) in humans, rats, and pigs.
  • To investigate the potential role of VEG proteins in saliva-tastant interactions.
  • To explore alternative functions for VEG proteins beyond potential hydrophobic molecule transport.

Main Methods:

  • Protein characterization of the 18 kDa VEG secretory protein.

Related Experiment Videos

  • Sequence identity analysis between human and rat VEG proteins.
  • Assessment of VEG proteins' potential binding to bitter substances.

    • Main Results:

    • A prominent 18 kDa secretory protein was identified in human, rat, and pig VEGs.
    • Human and rat VEG proteins exhibit 60% sequence identity and belong to the lipocalin superfamily.
    • Binding experiments with bitter substances were unsuccessful, suggesting other functions.

    Conclusions:

    • VEG proteins are lipocalin-type proteins potentially involved in transporting hydrophobic molecules, similar to nasal odorant-binding proteins.
    • Given the failure of binding experiments and species-specific expression, other functions like epithelial protection, pheromone transport, or lipid binding are considered.
    • Further research is needed to determine the precise function of VEG proteins in the gustatory system.