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Blood transfusion and survival in colorectal cancer
D M Sibbering1, A P Locker, J D Hardcastle
1Department of Surgery, University Hospital, Queen's Medical Centre, Nottingham, United Kingdom.
Purpose:
This study examined the effect of blood transfusion on the prognosis of patients undergoing surgery for colorectal cancer.
Methods:
Potentially curative resections for colorectal cancer were performed in 266 patients who were followed prospectively, with a minimum follow-up of 41 months. They were divided into transfused (n = 121) and nontransfused (n = 145) groups according to their perioperative blood transfusion requirements.
Results:
There were significantly more rectal tumors (chi 2 = 9.5, df = 1, P = 0.002) and fixed tumors (chi 2 = 4.5, df = 1, P = 0.03) in the transfused group. There was no statistically significant difference between the two groups with regard to recurrence-free survival (chi 2 = 1.1, df = 1, P = 0.3) and overall survival (chi 2 = 2.8, df = 1, P = 0.09).
Conclusion:
In this study we have found no statistically significant effect of perioperative blood transfusion on the prognosis of colorectal cancer patients.