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Continuous intravenous heparin administration in humans causes a decrease in serum lipolytic activity and
M Weintraub1, T Rassin, S Eisenberg
1Department of Internal Medicine C, Tel Aviv Medical Center, Israel.
Journal of Lipid Research
|February 1, 1994
Summary
Heparin administration significantly alters fat metabolism, leading to increased chylomicrons and decreased lipolytic activity. This study reveals heparin
Area of Science:
- Biochemistry
- Pharmacology
- Cardiovascular Medicine
Background:
- Heparin is a widely used anticoagulant.
- Heparin influences fat metabolism, impacting postprandial lipoproteins.
- Postprandial lipoproteins are implicated in coronary heart disease development.
Purpose of the Study:
- To evaluate the effects of continuous heparin administration on postprandial lipoprotein metabolism.
- To assess changes in chylomicron levels and lipolytic activity during heparin treatment.
Main Methods:
- Vitamin A-fat loading tests were conducted before and during heparin administration.
- Retinyl palmitate (RP) concentrations in chylomicron and nonchylomicron fractions were measured.
- Postheparin lipoprotein lipase (LPL) activity was assessed.
Main Results:
- Four days of heparin increased the chylomicron RP curve area (P < 0.003).
- Acute heparin administration reduced the chylomicron fraction area (P < 0.05).
- Postheparin LPL activity significantly decreased after 4 days of heparin (P < 0.0005).
Conclusions:
- Continuous heparin administration for 4 days leads to chylomicron accumulation.
- This accumulation is likely due to a marked decrease in serum lipolytic activity.
- Heparin's effects on lipoprotein metabolism warrant consideration in clinical practice.